MODE OF ACTION OF STREPTOMYCIN ON TYPE b HEMOPHILUS INFLUENZAE

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MODE OF ACTION OF STREPTOMYCIN ON TYPE b HEMOPHILUS INFLUENZAE

In all of ten strains of H. influenzae examined prior to exposure to streptomycin a very small fraction of the bacteria formed colonies in the presence of 1,000 units of streptomycin per cc. These variant organisms possess the characteristics of bacterial mutants. 1. Different independent cultures of the same strain on different occasions, and even cultures seeded in a single test with the same...

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MODE OF ACTION OF STREPTOMYCIN ON TYPE b H. INFLUENZAE

1. Of fourteen patients with type b H. influenzae infections treated with streptomycin alone ten recovered promptly; in three of the four remaining cases failure was proved to be due to emergence of resistance of the organisms to streptomycin. 2. The rapid development of resistance to 1000 units of streptomycin per cc. during treatment argues against metabolic adaptation of the bacteria. 3. Car...

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Hemophilus influenzae type b pneumonia.

SUMMARY Thirteen patients with Haemophilus influenzae type b pneumonia are reported to emphasise the clinical, radiographic, and therapeutic aspects of this illness. All but one patient was tnder 21 years of age. The presenting complaint was a variable duration of upper respiratory infection and fever in most cases. One-third of patients had radiographic evidence of pleural involvement ; one-th...

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Hemophilus influenzae type B cellulitis in adults.

Cellulitis due to Hemophilus influenzae type B is a rare but treatable event in adults. Herein is described a 67-year-old woman with anterior neck cellulitis caused by H. influenzae type B, documented by positive blood culture results. Six additional cases reported in the literature are reviewed. The following clinical syndrome emerges: the patient is usually older than 50 years of age, and pha...

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The Action of Type-specific Hemophilus Influenzae Antiserum

In this communication, further evidence has been given which supports the view that the majority of the strains of Hemophilus influenzae giving rise to meningitis are of the same serological type. Forty strains have now been examined, and thirty-seven have been of Type b. A horse has been artificially immunized with Type b strains isolated from the spinal fluid of patients. By precipitation tes...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1947

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.85.6.607